Office 2007 dk.nrg

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    1900 Board of Nursing - Delaware Regulations - Home Page

    Thus, this disclosure also comtemplates fusion proteins comprising such Cas9 variants and a DNA modifying domain e.g., a deaminase, a nuclease, a nickase, a recombinase, a methyltransferase, a methylase, an acetylase, an acetyltransferase, a transcriptional activator, or a transcriptional repressor domain as well as the use of such fusion proteins in correcting mutations in a genome e.g., the genome of a human subject) that are associated with disease, or generating mutations in a genome e.g., the human genome) to decrease or prevent expression of a gene. 0009 In some embodiments.

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